Acceptance-based behavior therapy for depression With psychosis: Results From a pilot feasibility randomized controlled trial

Acceptance-based depression and psychosis therapy (ADAPT), a mindfulness/acceptance-based behavioral activation treatment, showed clinically significant effects in the treatment of depression with psychosis in a previous open trial. The goal of the current study was to further test the feasibility of ADAPT to determine the utility of testing it in a future clinical trial, following a stage model of treatment development. Feasibility was determined by randomizing a small number of patients (N=13) with comorbid depression and psychosis to medication treatment as usual plus enhanced assessment and monitoring versus ADAPT for 4 months of outpatient treatment. Both conditions were deemed acceptable by patients. Differences in between-subjects effect sizes favored ADAPT posttreatment and were in the medium to large range for depression, psychosocial functioning, and experiential avoidance (ie, the target mechanism). Thus ADAPT shows promise for improving outcomes compared with medications alone and requires testing in a fully powered randomized trial.

Title	Acceptance-based behavior therapy for depression With psychosis: Results From a pilot feasibility randomized controlled trial
Creator	Epstein-Lubow, G.
	Miller, I. W.
	Nowlan, K.
	Busch, A. M.
	Wenze, Susan J.
	Gaudiano, B. A.
Publisher	Journal of Psychiatric Practice
Academic Department	Psychology
Division	Natural Sciences
Organization	Lafayette College
Date Issued	2015
Date Available	2019-01-04T16:20:50Z
Type	Article
Language	English
Keyword	behavioral activation
	major depression with psychotic features
	treatment development
	schizophrenia
	acceptance and commitment therapy
	acceptance-based depression and psychosis therapy (ADAPT)
Bibliographic Citation	Gaudiano, B. A. (2015) "Acceptance-based behavior therapy for depression With psychosis: Results From a pilot feasibility randomized controlled trial." Journal of Psychiatric Practice 21 (5): 320-333.
Standard Identifier	Handle 10385/2534
Standard Identifier	DOI 10.1097/PRA.0000000000000092
Permalink	http://hdl.handle.net/10385/2534
Rights Statement	In Copyright
Rights Holders	Wolters Kluwer Health, Inc.