Mechanotransduction activity facilitates hair cell toxicity caused by the heavy metal cadmium
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Abstract
- Hair cells are sensitive to many insults including environmental toxins such as heavy
metals. We show here that cadmium can consistently kill hair cells of the zebrafish
lateral line. Disrupting hair cell mechanotransduction genetically or pharmacologically
significantly reduces the amount of hair cell death seen in response to cadmium,
suggesting a role for mechanotransduction in this cell death process, possibly as
a means for cadmium uptake into the cells. Likewise, when looking at multiple
cilia-associated gene mutants that have previously been shown to be resistant to
aminoglycoside-induced hair cell death, resistance to cadmium-induced hair cell death
is only seen in those with mechanotransduction defects. In contrast to what was seen
with mechanotransduction, significant protection was not consistently seen from other
ions previously shown to compete for cadmium uptake into cells or tissue including zinc
and copper. These results show that functional mechanotransduction activity is playing
a significant role in cadmium-induced hair cell death.
| Title | Mechanotransduction activity facilitates hair cell toxicity caused by the heavy metal cadmium |
|---|---|
| Creator | Tarcza, K. |
| Alampi, I. | |
| Briggs, J. | |
| Stawicki, Tamara M. | |
| Schmid, C. | |
| Publisher | Frontiers in Cellular Neuroscience |
| Academic Department | Neuroscience |
| Division | Natural Sciences |
| Organization | Lafayette College |
| Date Issued | February 2020 |
| Date Available | 2020-02-24 |
| Type | Article |
| Language | English |
| Keyword | hair cells |
| cadmium | |
| heavy metals | |
| ototoxicity | |
| zebrafish | |
| Bibliographic Citation | Schmid, C., et al. (2020 Feb.) "Mechanotransduction activity facilitates hair cell toxicity caused by the heavy metal cadmium." Frontiers in Cellular Neuroscience 14: Article 37. |
| Standard Identifier | Handle 10385/n296wz56p |
| Permalink | http://hdl.handle.net/10385/n296wz56p |
| Rights Statement |
Creative Commons - Attribution
|
| Rights Holders | Tarcza, K. |
| Alampi, I. | |
| Briggs, J. | |
| Stawicki, Tamara M. | |
| Schmid, C. |
Contains
| File | Stawicki-FrontiersinCellularNeuroscience-vol14-2020.pdf | Uploaded 2020-02-24 | Public | Download |
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