An Electron Microscopic Study of the Effects of 5-thio-D-glucose on the Cerebral Cortices of Mice

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Abstract
  • 5-thio-D-glucose, a male contraceptive, when injected intraperitoneally at a daily dosage level of 35 mg/kg for a maximum period of five weeks, produced no ultrastructural changes in the cerebral cortices of skin tumor susceptible (STS) mice. Both neurons and neuroglia were examined and overall cellular arrangements, individual cell structure and cell organelles and processes were studied. The pyramidal cells of both the control and experimental groups exhibited normal cell bodies, axons and dendrites. The neuroglial cells of each group showed no pathological changes in structure or number. Intracellularly, organelles of both the neurons and neuroglia appeared normal.
TitleAn Electron Microscopic Study of the Effects of 5-thio-D-glucose on the Cerebral Cortices of Mice
CreatorMajumdar, Shyamal K.
Gall, J. R.
PublisherProceedings of the Pennsylvania Academy of Science
Academic DepartmentBiology
DivisionNatural Sciences
OrganizationLafayette College
Date Issued1978
Date Available2023-06-26
TypeArticle
LanguageEnglish
Bibliographic CitationGall, J. R. and S. K. Majumdar (1978) "An Electron Microscopic Study of the Effects of 5-thio-D-glucose on the Cerebral Cortices of Mice." Proceedings of the Pennsylvania Academy of Science 52 (2): 161-164.
Standard IdentifierHandle 10385/ms35tb240
Permalinkhttp://hdl.handle.net/10385/ms35tb240
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Rights HoldersPenn State University Press
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