Tumor-derived CCL2 Does Not Contribute to Disease Progression in Mice Bearing the 4T1 Murine Mammary Carcinoma

CCL2 has been correlated with disease severity in patients with breast cancer. To evaluate the role of CCL2 in disease progression in a murine breast cancer model we used the 4T1 tumor which spontaneously metastasizes and constitutively produces CCL2. For this purpose, CCL2⁻4T1 cells were generated and compared to CCL2⁺4T1 cells with regard to disease progression. We report that although the decrease in tumor-derived CCL2 expression influenced lymphocyte and monocyte recruitment, matrix metalloproteinase-9 expression and invasiveness of the tumor cells were not significantly altered by modulating tumor-derived CCL2 expression. Moreover, tumor growth and metastatic ability were not significantly influenced by CCL2 expression. These data indicate that tumor-derived CCL2 expression alone does not contribute to progression of disease in mice bearing the 4T1 murine mammary carcinoma.

Title	Tumor-derived CCL2 Does Not Contribute to Disease Progression in Mice Bearing the 4T1 Murine Mammary Carcinoma
Creator	Kurt, Robert A.
	Lepre, J. V.
	Marinucci, M. N.
	Stormes, K. A.
Publisher	Journal of the Pennsylvania Academy of Science
Academic Department	Biology
Division	Natural Sciences
Organization	Lafayette College
Date Issued	December 2008
Date Available	2023-06-26
Type	Article
Language	English
Bibliographic Citation	Stormes, K. A. (2008) "Tumor-derived CCL2 Does Not Contribute to Disease Progression in Mice Bearing the 4T1 Murine Mammary Carcinoma." Journal of the Pennsylvania Academy of Science 82 (2/3): 67-73.
Standard Identifier	Handle 10385/9019s4152
Permalink	http://hdl.handle.net/10385/9019s4152
Rights Statement	In Copyright
Rights Holders	Penn State University Press