Relationship between the TP53 SNP rs1800371 and lung cancer in African Americans

Germline and somatic mutations in TP53 have been investigated and intensely catalogued. One of these germline mutations, TP53 P47S SNP is only found in populations with African ancestry. The S47 variant was associated with an impaired ability to induce cell death following cisplatin treatment, and with a high rate of spontaneous cancer formation in mice engineered to carry S47. Lung cancer incidence is higher among men of African descent. We therefore tested the hypothesis that P47S was associated with increased risk of lung cancer. We included 926 controls and 425 cases, all of whom were African Americans. We genotyped rs1800371 using a predesigned Taqman assay. No serine/serine genotypes were detected in the population. The proline/serine genotype was detected in 42 individuals (32/891 controls (3.5%) and 10/434 cases (2.3%). The serine allele was not associated with risk of lung cancer (OR: 0.65, 95% C.I. 0.28-1.48). rs1800371 is not associated with risk of lung cancer among African Americans.

Title	Relationship between the TP53 SNP rs1800371 and lung cancer in African Americans
Creator	Nichols, N.
	Meaney, C.
	Bowman, E. D.
	Ryan, B. M.
	Mitchell, Khadijah
	Zingone, A.
Publisher	Cancer Health Disparities
Academic Department	Biology
Division	Natural Sciences
Organization	Lafayette College
Date Issued	2019
Date Available	2019-12-03
Type	Article
Language	English
Keyword	TP53
	health disparities
	SNP
Bibliographic Citation	Nichols, N., et al. (2019) “Relationship between the TP53 SNP rs1800371 and lung cancer in African Americans.” Cancer Health Disparities 3: e1-e9.
Standard Identifier	DOI 10.9777/chd.2019.1005.
Standard Identifier	Handle 10385/3r074v373
Permalink	http://hdl.handle.net/10385/3r074v373
Rights Statement	In Copyright
Rights Holders	Company of Scientists