We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.
Title
Trematocidal activity of praziquantel and artemisinin derivatives: In vitro and in vivo investigations with adult Echinostoma caproni
Keiser, J., et al. (2006) " Trematocidal activity of praziquantel and artemisinin derivatives: In vitro and in vivo investigations with adult Echinostoma caproni." Antimicrobial Agents and Chemotherapy 50 (2): 803-805.