Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
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Abstract
- Reducing or eliminating persistent disparities in lung cancer incidence and survival has been
challenging because our current understanding of lung cancer biology is derived primarily
from populations of European descent. Here we show results from a targeted sequencing
panel using NCI-MD Case Control Study patient samples and reveal a significantly higher
prevalence of PTPRT and JAK2 mutations in lung adenocarcinomas among African Americans
compared with European Americans. This increase in mutation frequency was validated with
independent WES data from the NCI-MD Case Control Study and TCGA. We find that
patients carrying these mutations have a concomitant increase in IL-6/STAT3 signaling and
miR-21 expression. Together, these findings suggest the identification of these potentially
actionable mutations could have clinical significance for targeted therapy and the enrollment
of minority populations in clinical trials.
| Title | Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans |
|---|---|
| Creator | Nichols, N. |
| Girvin, A. T. | |
| Pine, S. R. | |
| Bowman, E. | |
| Walling, J. | |
| Waterfall, J. | |
| Weingartner, E. | |
| Edelman, D. C. | |
| Stefanescu, R. | |
| Stevenson, H. | |
| Rossi, E. L. | |
| Meltzer, P. | |
| Sinha, S. | |
| Lack, J. | |
| Ryan, B. M. | |
| Arauz, R. F. | |
| Mitchell, Khadijah | |
| Zingone, A. | |
| Tang, W. | |
| Simmons, J. | |
| Pineda, M. | |
| Zhu, Y. J. | |
| Publisher | Nature Communications |
| Academic Department | Biology |
| Division | Natural Sciences |
| Organization | Lafayette College |
| Date Issued | 2019 |
| Date Available | 2019-12-19 |
| Type | Article |
| Language | English |
| Bibliographic Citation | Mitchell, K., et al. (2019) "Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans." Nature Communications 10: 5735 |
| Standard Identifier | Handle 10385/sx61dm961 |
| DOI 10.1038/s41467-019-13732-y | |
| Permalink | http://hdl.handle.net/10385/sx61dm961 |
| Rights Statement |
Creative Commons - Attribution
|
| Rights Holders | Springer Nature |
Contains
| File | Mitchell-NatureCommunications-vol10-2019.pdf | Uploaded 2019-12-19 | Public | Download |
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